Persistent Inflammation Rapid Test

Inflammation is the body's natural response to healing damaged tissue and is quite a common occurrence. However, when persistent inflammation becomes counterproductive to your health and starts to become an ever-present issue, it’s vital to recognise and diagnose the problem before your symptoms worsen.

Our easy-to-use Persistent Inflammation Test only requires a blood sample and can be done in the comfort of your own home. The test measures levels of serum amyloid A (SAA) proteins, which indicate inflammatory activity. Elevated SAA levels suggest that your persistent inflammation may have progressed to a chronic state, posing potential health risks.

Serum amyloid A (SAA) proteins play various roles, such as transporting cholesterol to the liver and recruiting immune cells to sites of inflammation. Understanding your SAA levels aids in diagnosing inflammation in your body. Elevated SAA levels may signal the need for further investigation into inflammation. 

The CE approved kit is dispatched immediately upon purchase and typically arrives within 1-3 working days. Inside, you'll find comprehensive instructions guiding you through how to complete the test and receive your results in just 10 minutes.

Persistent Inflammation Symptoms

Anyone can suffer from chronic inflammation, so even if you think you live a pretty healthy lifestyle, it won’t make you immune. To trigger acute inflammation, all it takes is an infection, an unhealthy diet, or obesity. Some common symptoms of chronic inflammation are:

• Pain
• Fatigue
• Depression
• Weight gain

In some cases, these symptoms can develop further, and major chronic illness symptoms could occur. These can include:

• Heart disease
• Diabetes
• Alzheimer’s Disease
• Cancer
• Arthritis

How It Works

The Persistent Inflammation Test Kit is easy to use and can be used in the comfort of your own home. The test utilises a lateral flow cassette to identify “serum amyloid A (SAA) protein” in whole blood, serum, or plasma.

The test cassette is pre-coated with anti-SAA antibodies in the test line region, so when the specimen containing SAA is applied, it migrates upward on the membrane via capillary action, reaching the test line region, where it reacts with anti-SAA antibodies to produce a visible coloured line.

A coloured line appearing in the test region indicates a positive result, while its absence indicates a negative result.

To ensure accurate results, a coloured line must appear in the control line region, confirming the correct addition of specimen volume and proper membrane absorption.

Serum amyloid A (SAA) proteins are produced predominantly by the liver and are usually in response to inflammation in the body.

The raised Serum amyloid A (SAA) gives an indicator of inflammation in the body and is especially useful for evaluating disease severity and monitoring disease activity in patients with rheumatoid arthritis and secondary amyloidosis.

▶ An SSA level higher than 10μIU/mL indicates a higher than normal level and a positive test.

The test provides results based on a Positive/Higher or Negative/Normal basis. Positive results can then be used to request a secondary test or consult further medical advice.

Serum amyloid A (SAA) proteins are a family of apolipoproteins associated with high-density lipoprotein (HDL) in plasma.

Different isoforms of SAA are expressed constitutively (constitutive SAAs) at different levels or in response to inflammatory stimuli (acute phase SAAs).

These proteins are produced predominantly by the liver (1). Acute-phase serum amyloid A proteins (A-SAAs) are secreted during the acute phase of inflammation.

These proteins have several roles, including the transport of cholesterol to the liver for secretion into the bile, the recruitment of immune cells to inflammatory sites, and the induction of enzymes that degrade the extracellular matrix.

Serum amyloid A (SAA) is also an acute-phase marker that responds rapidly. It has been suggested that SAA levels correlate better with disease activity in early inflammatory joint disease than do ESR and CRP.

Although largely produced by hepatocytes, more recent studies show that SAA is produced by adipocytes as well, and its serum concentration is associated with body mass index (2,3).

▶ REFERENCES:

1. https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1327.1999.00657.x
2. https://pubmed.ncbi.nlm.nih.gov/27126803/
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695410/